(A) Immunofluorescence staining of Dsg2 and Dsg3 in 5d SCC9 cells. Because barrier properties of epithelial cells were shown to depend on the function of...Adducins tightly regulate actin dynamics which is critical for endothelial barrier function. Gu...Desmoplakin (Dp) localizes to desmosomes, linking clusters of desmosomal adhesion molecules to the intermediate filament cytoskeleton. Patients with the blistering skin disease pemphigus vulgaris (PV), which is caused by autoantibodies against desmosomal cadherins, often have dry eye disease. Pauletta Pollmann. Uncertainties can be social, political, geopolitical, economic, environmental, or technological. IMPRESSUM DATENSCHUTZ
The Times-Picayune obituaries and Death Notices for New Orleans Louisiana area . Dsg3 in...When preparing young medical students for clinical activity, it is indispensable to acquaint them with anatomical section images which enable them to use the clinical application of imaging methods A new Augmented Reality Magic Mirror (AR MM) system, which provides the advantage of a novel, interactive learning tool in addition to a regular dissect...The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions.
Recent data indicated t...Background: Here, we characterized the mechanisms engaged by pemphigus IgG from patients with different clinical phenotypes and autoantibody profiles. For desmosome assembly, constitutively synthesized desmosomal cadherins translocate to the cell-cell border, cluster and mature in the presence of Ca(2+) to stable cell contacts. Rapid Ca2+ influx induced by both histamine and thrombin was accompanied by endothelial barrier breakdown revealed as drop...Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells, and are essential for the mechanical integrity of mammalian tissues. November 2002. All pemphigus vulgaris (PV) and pemphigus foliaceus (PF) IgG and AK23, a monoclonal mouse an...Autoimmune blistering diseases are a heterogeneous group of about a dozen complex disorders that are characterized by intraepidermal (pemphigus) and subepidermal blistering (pemphigoid diseases and dermatitis herpetiformis). Confluent keratinocyte monolayers were exposed to PV-IgG or AK23 for 24 h. Respective controls were run in parallel. Therefore, we studied the regulation of cell cohesion in human meibomia...NHEK monolayers treated with c-IgG, AK23 and PV-IgG were immunostained for Dsg3. Geburtstag: 22. Samuel Benito Here we used atomic force microscopy (AFM) to simultaneously visualize the topography of living human keratinocyt...Desmosomes are adhering junctions present in all cells of simple and complex epithelia. Fidel Weimer (a) Pp2 treatment for 2 h prevented EGF-mediated loss of cell cohesion, whereas pp2 alone had no effect compared to controls (n = 6, *p < 0.05). Mounting evidence suggests that desmosomes, which together with tight juncti...Arrhythmogenic cardiomyopathy (AC) is a genetic disease causing arrhythmia and sudden cardiac death with only symptomatic therapy available at present. Jakob Wild In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is closely associated with N-cadherin and gap junctions. Tight regulation of PKA function can be achieved by discrete compartmentalization of the enzyme via physical interaction with A-kinase anchoring proteins (AKAPs). Jonathan Dannenberg Ben Felipe (B) Expression profile of desmosomal cadherins in 5d HaCaT and 5d SCC9 cells. Patients may suffer conjunctival involvement, yet the underlying mechanisms are largely unclear. The mechanisms underlying loss of intestinal epithelial barrier (IEB) function in Crohn's disease (CD) are poorly understood. Kolja Rashed Desmosomes are primarily considered to mediate strong intercellular cohesion. The two main signaling axes downstream of cAMP are activation of protein kinase A (PKA) as well as engagement of exchange protein directly activated by cAMP (Epac) and...Education of anatomy is a challenging but crucial element in educating medical professionals, but also for general education of pupils. Maya Lauterbach